Recombinant:Article Title: AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Phospho-EGF Receptor (Tyr1068) Antibody Cell Signaling Technology Cat2234; RRID:AB_331701 EGF Receptor (D38B1) XP Rabbit mAb Cell Signaling Technology Cat#4267; RRID:AB_2246311 Phospho-p44/42 MAPK (Erk1/2) (Thr202/ Tyr204) Antibody Cell Signaling Technology Cat#9101; RRID:AB_331646 p44/42 MAPK (Erk1/2) Antibody Cell Signaling Technology Cat#9102; RRID:AB_330744 Phospho-Akt (Ser473) (D9E) XP Rabbit mAb Cell Signaling Technology Cat#4060; RRID:AB_2315049 Akt Antibody Cell Signaling Technology Cat#9272; RRID:AB_329827 Phospho-S6 Ribosomal Protein (Ser235/ 236) (D57.2.2E) XP Rabbit mAb Cell Signaling Technology Cat#4858; RRID:AB_916156 S6 Ribosomal Protein (54D2) Mouse mAb Cell Signaling Technology Cat#2317; RRID:AB_2238583 Biological Samples LU3075 Crown Bioscience N/A LU0387 Crown Bioscience N/A Chemicals, peptides, and recombinant proteins AZ14289671 AstraZeneca N/A Mobocertinib AstraZeneca N/A Zipalertinib AstraZeneca N/A Sunvozertinib AstraZeneca N/A Critical commercial assays HTRF Human Phospho-EGFR (Tyr1068) Detection Kit Revvity Part #: 64EG1PEG HTRF Human and Mouse Phospho-ERK (Thr202/Tyr204) Detection Kit Revvity Part #: 64AERPET Deposited data Original code used to compare the growth rate inhibition or potency of the compounds tested This paper https://doi.org/10.5281/zenodo.15534119 Experimental models: Cell lines NCI-H2073 ATCC CRL-5918; RRID:CVCL_1521 LXF2478 Oncotest N/A .. HaCaT Professor Norbert E. Fusenig in Deutsches Krebsforschungszentrum (DKFZ) N/A NCI-H2073 EGFRD770-N771InsSVD AstraZeneca Generated as previously described by Floc’h et al.3 NCI-H2073 EGFRV769-D770InsASV AstraZeneca Generated as previously described by Floc’h et al.3 NCI-H2073 EGFRD770-N771InsNPG AstraZeneca Generated as previously described by Floc’h et al.3 Experimental models: Organisms/strains Mouse: SCID: C.B-17/IcrHanHsd-Prkdcscid Envigo UK N/A Mouse: Nude: Hsd:Athymic Nude-Foxn1nu Envigo UK N/A Mouse: Balb/c Nude: BALB/cNj-Foxn1nu/ Gpt GemPharmatech Co., Ltd N/A (Continued on next page) Cell Reports Medicine 6, 102305, September 16, 2025 e1 Article ll OPEN ACCESS
Inhibition:Article Title: AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Phospho-EGF Receptor (Tyr1068) Antibody Cell Signaling Technology Cat2234; RRID:AB_331701 EGF Receptor (D38B1) XP Rabbit mAb Cell Signaling Technology Cat#4267; RRID:AB_2246311 Phospho-p44/42 MAPK (Erk1/2) (Thr202/ Tyr204) Antibody Cell Signaling Technology Cat#9101; RRID:AB_331646 p44/42 MAPK (Erk1/2) Antibody Cell Signaling Technology Cat#9102; RRID:AB_330744 Phospho-Akt (Ser473) (D9E) XP Rabbit mAb Cell Signaling Technology Cat#4060; RRID:AB_2315049 Akt Antibody Cell Signaling Technology Cat#9272; RRID:AB_329827 Phospho-S6 Ribosomal Protein (Ser235/ 236) (D57.2.2E) XP Rabbit mAb Cell Signaling Technology Cat#4858; RRID:AB_916156 S6 Ribosomal Protein (54D2) Mouse mAb Cell Signaling Technology Cat#2317; RRID:AB_2238583 Biological Samples LU3075 Crown Bioscience N/A LU0387 Crown Bioscience N/A Chemicals, peptides, and recombinant proteins AZ14289671 AstraZeneca N/A Mobocertinib AstraZeneca N/A Zipalertinib AstraZeneca N/A Sunvozertinib AstraZeneca N/A Critical commercial assays HTRF Human Phospho-EGFR (Tyr1068) Detection Kit Revvity Part #: 64EG1PEG HTRF Human and Mouse Phospho-ERK (Thr202/Tyr204) Detection Kit Revvity Part #: 64AERPET Deposited data Original code used to compare the growth rate inhibition or potency of the compounds tested This paper https://doi.org/10.5281/zenodo.15534119 Experimental models: Cell lines NCI-H2073 ATCC CRL-5918; RRID:CVCL_1521 LXF2478 Oncotest N/A .. HaCaT Professor Norbert E. Fusenig in Deutsches Krebsforschungszentrum (DKFZ) N/A NCI-H2073 EGFRD770-N771InsSVD AstraZeneca Generated as previously described by Floc’h et al.3 NCI-H2073 EGFRV769-D770InsASV AstraZeneca Generated as previously described by Floc’h et al.3 NCI-H2073 EGFRD770-N771InsNPG AstraZeneca Generated as previously described by Floc’h et al.3 Experimental models: Organisms/strains Mouse: SCID: C.B-17/IcrHanHsd-Prkdcscid Envigo UK N/A Mouse: Nude: Hsd:Athymic Nude-Foxn1nu Envigo UK N/A Mouse: Balb/c Nude: BALB/cNj-Foxn1nu/ Gpt GemPharmatech Co., Ltd N/A (Continued on next page) Cell Reports Medicine 6, 102305, September 16, 2025 e1 Article ll OPEN ACCESS
|
Cell Signaling Technology Inc is a verified supplier 
Cell Signaling Technology Inc manufactures this product 